์ •๋ฆฌ

์นจ์น˜๋ฃŒ ํ›„ 48~72์‹œ๊ฐ„ ์œ„์„ฑ์„ธํฌ์˜ ํ™œ์„ฑํ™” ๋ฐ ํ˜ˆ๋ฅ˜ ์ •์ƒํ™”

MANYFAST 2025. 8. 28. 20:01
๋ฐ˜์‘ํ˜•

๐Ÿงฌ 1. ์œ„์„ฑ์„ธํฌ(satellite cell) ํ™œ์„ฑํ™”์™€ ๊ทผ์„ฌ์œ  ์žฌ์ƒ

  • ์œ„์„ฑ์„ธํฌ๋ž€?
    • ๊ทผ์„ฌ์œ (basal lamina์™€ sarcolemma ์‚ฌ์ด)์— ์œ„์น˜ํ•˜๋Š” ์„ฑ์ฒด ๊ทผ์œก ์ค„๊ธฐ์„ธํฌ
    • ํ‰์†Œ์—๋Š” ํœด์ง€๊ธฐ(quiescent) ์ƒํƒœ
    • ์†์ƒ ์‹œ ๋น ๋ฅด๊ฒŒ ํ™œ์„ฑํ™”๋˜์–ด ๊ทผ์œก ์žฌ์ƒ์˜ ํ•ต์‹ฌ ์—ญํ•  ์ˆ˜ํ–‰
  • ํ™œ์„ฑํ™” ๊ณผ์ • (TP ์ž์นจ → ๊ทผ์„ฌ์œ  ๋ฏธ์„ธ์†์ƒ ์œ ๋ฐœ ํ›„ 48h ์ „ํ›„)
    1. ์†์ƒ๋œ ๊ทผ์„ฌ์œ  ์ฃผ๋ณ€์—์„œ HGF (Hepatocyte Growth Factor), FGF (Fibroblast Growth Factor), NO (Nitric oxide) ๋ถ„๋น„
    2. ์œ„์„ฑ์„ธํฌ๊ฐ€ quiescent → activated ์ƒํƒœ๋กœ ์ „ํ™˜
    3. MyoD, Myf5 ๋ฐœํ˜„ → myoblast๋กœ ๋ถ„ํ™”
    4. proliferation (์„ธํฌ ๋ถ„์—ด) ํ›„ ์ผ๋ถ€๋Š” ์ƒˆ๋กœ์šด ๊ทผ์„ฌ์œ ๋กœ ์œตํ•ฉ (myotube ํ˜•์„ฑ)
    5. ์ผ๋ถ€๋Š” ๋‹ค์‹œ ํœด์ง€์„ธํฌ๊ตฐ์œผ๋กœ ๋‚จ์•„ ๊ทผ์œก ์žฌ์ƒ pool ์œ ์ง€
  • ์ž„์ƒ์  ์˜๋ฏธ
    → ์ž์นจ์ด ๋‹จ์ˆœํ•œ ํ†ต์ฆ ์ฐจ๋‹จ์ด ์•„๋‹ˆ๋ผ, ๋ฏธ์„ธ์†์ƒ์„ ์œ ๋„ํ•˜์—ฌ ์œ„์„ฑ์„ธํฌ๋ฅผ ํ™œ์„ฑํ™” → ์žฅ๊ธฐ์ ์œผ๋กœ ๊ทผ์œก ๊ธด์žฅ ์™„ํ™” + ์กฐ์ง ์žฌ์ƒ ํšจ๊ณผ

 

๐Ÿ’‰ 2. ํ˜ˆ๋ฅ˜ ์ •์ƒํ™”์™€ ๋ฏธ์„ธํ™˜๊ฒฝ ๊ฐœ์„ 

  • ์†์ƒ ์ดˆ๊ธฐ (0~24h)
    • ๋ชจ์„ธํ˜ˆ๊ด€ ์†์ƒ → ๊ตญ์†Œ ๋ถ€์ข…, ์ผ์‹œ์  ํ—ˆํ˜ˆ
    • ์ –์‚ฐ, Hโบ, ๋ธŒ๋ž˜๋””ํ‚ค๋‹Œ ๋“ฑ ํ†ต์ฆ๋ฌผ์งˆ ์ถ•์ 
  • 48~72h ์ „ํ™˜๊ธฐ
    • ํ˜ˆ๊ด€ ๋‚ดํ”ผ์„ธํฌ์—์„œ VEGF (Vascular Endothelial Growth Factor) ๋ถ„๋น„ → ์‹ ์ƒํ˜ˆ๊ด€(angiogenesis) ์ด‰์ง„
    • ๋ฏธ์„ธํ˜ˆ๋ฅ˜๊ฐ€ ํšŒ๋ณต๋˜๋ฉด์„œ ์‚ฐ์†Œ ๊ณต๊ธ‰๊ณผ ์˜์–‘๋ถ„ ์œ ์ž… ↑
    • ๋Œ€์‚ฌ์‚ฐ๋ฌผ(์ –์‚ฐ, ROS) ์ œ๊ฑฐ๊ฐ€ ๋นจ๋ผ์ง€๊ณ  pH ์ •์ƒํ™”
  • ๊ฒฐ๊ณผ
    → ํ†ต์ฆ ์œ ๋ฐœ ๋ฌผ์งˆ ๊ฐ์†Œ, ๊ทผ์„ฌ์œ  ํšŒ๋ณต ํ™˜๊ฒฝ ์กฐ์„ฑ
    → ์‚ฐ์†Œ ๊ณต๊ธ‰ ์ฆ๊ฐ€๋กœ ATP ์žฌํ•ฉ์„ฑ ์›ํ™œ → ๊ทผ์œก ํ”ผ๋กœ ํšŒ๋ณต

 

 

๐Ÿ”— 3. ์™œ ์ด ์‹œ์ ์—์„œ “์ด์™„ ํšจ๊ณผ”๊ฐ€ ๋‚˜ํƒ€๋‚˜๋Š”๊ฐ€?

  • ์œ„์„ฑ์„ธํฌ ํ™œ์„ฑํ™”๋กœ ์†์ƒ๋œ ๊ทผ์„ฌ์œ ๊ฐ€ ๋ณต๊ตฌ๋˜๋ฉฐ ๊ตฌ์กฐ์  ๊ธด์žฅ ํ•ด์†Œ
  • ํ˜ˆ๋ฅ˜ ๊ฐœ์„ ์œผ๋กœ ๋Œ€์‚ฌ์‚ฐ๋ฌผ์ด ์ œ๊ฑฐ๋˜๊ณ , nociceptor ๋ฏผ๊ฐ๋„ ์ •์ƒํ™”
  • ์ค‘์ถ” ๊ฐ์ž‘๋„ ์ง„์ •๋˜๋ฉด์„œ “ํ†ต์ฆ → ๊ธด์žฅ → ํ†ต์ฆ” ์•…์ˆœํ™˜์ด ์ฐจ๋‹จ

 

 

๐Ÿ“Œ ์ •๋ฆฌ

48~72์‹œ๊ฐ„ ์žฌ์ƒ·์ด์™„๊ธฐ๋Š” ๋‹จ์ˆœํžˆ ํ†ต์ฆ์ด ์ค„์–ด๋“œ๋Š” ์‹œ๊ฐ„์ด ์•„๋‹ˆ๋ผ,

  • ์œ„์„ฑ์„ธํฌ๊ฐ€ ํ™œ์„ฑํ™”๋˜์–ด ์ƒˆ๋กœ์šด ๊ทผ์„ฌ์œ  ์žฌ์ƒ์ด ์‹œ์ž‘๋˜๊ณ 
  • VEGF ๋งค๊ฐœ ํ˜ˆ๋ฅ˜ ํšŒ๋ณต์œผ๋กœ ๋Œ€์‚ฌํ™˜๊ฒฝ์ด ์ •์ƒํ™”๋˜๋Š” ์‹œ์ ์ž…๋‹ˆ๋‹ค.
    ์ฆ‰, TP ์ž์นจ์ด ๋‹จ์ˆœ ์ง„ํ†ต์ด ์•„๋‹ˆ๋ผ ๊ทผ์œก ์žฌ์ƒ ํ”„๋กœ์„ธ์Šค๋ฅผ ์ด‰๋ฐœํ•˜๋Š” ์น˜๋ฃŒ์  ์ž๊ทน์ด๋ผ๋Š” ์ ์ด ์ž„์ƒ์ ์œผ๋กœ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค.
๋ฐ˜์‘ํ˜•